Grape seed extract ameliorates bleomycin-induced mouse pulmonary fibrosis
نویسندگان
چکیده
منابع مشابه
Saffron Protection against Bleomycin-Induced Pulmonary Fibrosis in Rats
Background: Bleomycin-induced lung fibrosis has been accepted as an animal model for fibrosis in rats. The aim of this study was to evaluate the effects of saffron aqueous extract on this disorder paving the way for more investigation in treating idiopathic pulmonary fibrosis in human. Methods: Male Wistar rats (250–300 gr) were instilled a single dose of bleomycin (5 mg/kg) via in...
متن کاملProtective Effects of Celery (Apium graveloens) Seed Extract on Bleomycin-Induced Pulmonary Fibrosis in Rats
BACKGROUND AND OBJECTIVE: Pulmonary fibrosis is one of the most common side effects of bleomycin which is used as a chemotherapeutic agent. Reactive oxygen species play a key role in the development of pulmonary fibrosis. Celery seed contains a variety of flavonoids which are considered as asantioxidants. This study investigated the effects of celery seed hydroalcoholic extract on bleomycin-ind...
متن کاملPreventive Effects of Pomegranate Seed Extract on Bleomycin-Induced Pulmonary Fibrosis in Rat
BACKGROUND Oxidative stress plays an important role in the pathogenesis of bleomycin-induced lung fibrosis and many antioxidant agents have been used for the treatment of this disease in animals. OBJECTIVES To evaluate the antioxidant effects of pomegranate seed extract (PSE) on bleomycin treated rats. MATERIALS AND METHODS Male Spraque - Dawley rats were divided into 5 groups: rats in grou...
متن کاملThe Effect of Methanol Extract of Fennel on Bleomycin-Induced Pulmonary Fibrosis in Rats
Background & Aims: Idiopathic pulmonary fibrosis (IPF) is a chronic diffuse interstitial lung disease, which has symptoms such as coughing and shortness of breath. The average survival duration in these patients is estimated as 3 years after the onset of symptoms. Today, the therapeutic approach used in IPF cases is the usage of chemical or herbal antioxidants in order to elim...
متن کاملpreventive effects of pomegranate seed extract on bleomycin-induced pulmonary fibrosis in rat
conclusions results of the present study showed that hydroalcoholic extracts of pomegranate seeds had a significant protective effect against bleomycin-induced lung fibrosis by its antioxidant properties. the highest protective effect was observed for the 400 mg/kg dose. results histological analysis showed that pse could prevent pathological changes that were seen in the bleomycin group. objec...
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ژورنال
عنوان ژورنال: Toxicology Letters
سال: 2017
ISSN: 0378-4274
DOI: 10.1016/j.toxlet.2017.03.012