Granzymes A and K differentially potentiate LPS-induced cytokine response
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چکیده
منابع مشابه
Extracellular Histones Enhance LPS-induced Cytokine Production
Over the last twenty years, the debilitating clinical condition known as sepsis has tripled in frequency to become the tenth leading cause of death in the United States. Extracellular histones were previously reported to mediate cell damage and organ dysfunction during hyperinflammatory response, a characteristic feature of sepsis. Lipopolysaccharide (LPS) is an endotoxin found in Gramnegative ...
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Granzymes are serine proteases released by cytotoxic lymphocytes to induce apoptosis in virus-infected cells and tumor cells. Evidence is emerging that granzymes also play a role in controlling inflammation. Granzyme serum levels are elevated in patients with autoimmune diseases and infections, including sepsis. However, the function of extracellular granzymes in inflammation largely remains un...
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Previously we identified a transcription factor, LPS-Induced TNF-alpha Factor (LITAF), mediating inflammatory cytokine expression in LPS-induced processes. To characterize the role of LITAF in vivo, we generated a macrophage-specific LITAF-deficient mouse (macLITAF(-/-)). Our data demonstrate that in macrophages (i) several cytokines (such as TNF-alpha, IL-6, sTNF-RII, and CXCL16) are induced a...
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Corylin is a main compound isolated from Psoralea corylifolia L. (Fabaceae). A variety of pharmacological effects such as antioxidant, anti-proliferation, and anti-inflammatory properties of corylin have been reported. Nevertheless, the effect of corylin in microbial infection and sepsis remains unclear. In the present study, we investigated the anti-inflammatory effects of corylin. Our experim...
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ژورنال
عنوان ژورنال: Cell Death Discovery
سال: 2016
ISSN: 2058-7716
DOI: 10.1038/cddiscovery.2016.84