Granulocyte transfusion therapy: randomization after all?

Granulocyte transfusion therapy: randomization after all?

A practical guide to granulocyte transfusion therapy.

A major development for the supportive care of patients with bone marrow suppression has been the recent introduction of techniques for collecting granulocytes from suitable donors. There is increasing awareness in this country that granulocyte transfusion for infected neutropenic patients is now a practical possibility, and the demand for granulocytes from those centres able to provide this se...

Granulocyte transfusion therapy of experimental Pseudomonas pneumonia.

Pseudomonas pneumonia was produced in dogs with radiation-induced leukopenia. Treatment of this infection with either gentamicin alone or gentamicin plus daily granulocyte transfusion was compared in a randomized controlled trail. The dogs receiving granulocytes plus gentamicin survived significantly longer than those treated with gentamicin alone (P < 0.05). The Pseudomonas immunotype which wa...

Current status of granulocyte (neutrophil) transfusion therapy for infectious diseases.

The transfusion of neutrophils, or granulocyte transfusion therapy, has long been considered as a logical approach to the treatment of severe bacterial and fungal infections in patients with prolonged neutropenia or intrinsic defects in neutrophil function. However, despite numerous clinical trials, the efficacy and safety of granulocyte transfusion therapy remain controversial. Efficacy has be...

Granulocyte transfusion in children.

We describe a single institution experience with the use of granulocyte transfusion in children. This is a retrospective analysis of 45 collections of granulocyte units obtained by apheresis after priming with dexamethasone, infused into 17 children with severe neutropenic infections. Ten children survived the acute infection. Granulocyte transfusion is a useful adjunct to antimicrobials and gr...