G‐protein‐coupled receptor (GPCR) regulation of acid‐sensing ion channel 1a

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Objective(s): Activation of acid-sensing ion channel 1a (ASIC1a) is responsible for tissue injury caused by acidosis in nervous systems. But its physiological and pathological roles in nucleus pulposus cells (NPCs) are unclear. The aim of this study is to investigate whether ASIC1a regulates the survival of NPCs in the acidic environment of degenerated discs. Materials and Methods: NPCs were i...

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ژورنال

عنوان ژورنال: The FASEB Journal

سال: 2007

ISSN: 0892-6638,1530-6860

DOI: 10.1096/fasebj.21.6.a1405-a