Gout, diuretics and the kidney

Gout, diuretics and the kidney.

G out is a monosodium urate crystal deposition disease. Formation of the crystals requires high serum uric acid levels; the local factors responsible for their predilection for the joints are only started to be grasped. 2 Steady serum urate levels result from the balance between its production and excretion; hyperuricaemia results when formation is increased or difficulties in (mostly) renal ex...

Modern diuretics and the kidney.

Uric acid, gout and the kidney.

Uric acid is 2,6,8-trihydroxypurine, and seems to be present in almost all organisms. In snakes, reptiles, birds and spiders it is the main end-product of all nitrogenous metabolism, and these groups of animals have kidneys which are capable of secreting large amounts of uric acid. This is then excreted as a slurry of crystals, which confers the advantage that the nitrogenous end-product can be...

Gout and Hyperuricemia in Chronic Kidney Disease

Diuretics in the Clinic

This article has no abstract.