Good T cells for bad B cells
نویسندگان
چکیده
منابع مشابه
ACAT inhibition: bad for macrophages, good for smooth muscle cells?
Ahallmark of the atherosclerotic plaque is the accumulation of lipid-laden foam cells that are derived from macrophages or smooth muscle cells (SMCs).1,2 Cholesterol from modified lipoproteins is taken up and either stored in intracellular lipid droplets or delivered to extracellular cholesterol acceptors. Cellular free cholesterol can be exported to nascent HDL and activate the reverse cholest...
متن کاملCD26+ Cord Blood Mononuclear Cells Significantly Produce B, T, and NK Cells
Background: Umbilical cord blood (UCB) is an alternative source of hematopoietic stem cell transplantation (HSCT), used in Leukemia treatment. CD26+ cells, a fraction of CD34 positive cells, are a major population of UCB cells which negatively regulate the in vivo homing and engraftment of HSCs. CD26 is highly expressed in various cells such as HSCs, immune cells, fibroblasts, and epithelial ce...
متن کاملTargeting “bad” B cells in multiple sclerosis
Laquinimod is an orally available quinoline 3carboxamide derivative drug studied in phase II and III clinical trials for relapsing-remitting multiple sclerosis (RRMS), systemic lupus erythematosus, and Crohn disease. Laquinimod has shown promise in RRMS clinical trials, and identifying the mechanism underlying its disease-modifying effects could help target it to the patient population where it...
متن کاملPersuading natural killer cells to eliminate bad B cells.
Clinical trials are underway infusing T cells genetically modified to be specific for B-cell malignancies using a chimeric antigen receptor (CAR) to redirect specificity for CD19. However, issues remain about whether the CAR can provide a fully competent application signal and whether other lymphocytes with lytic capacity can target CD19(+) tumors.
متن کاملImpact of T cells on hematopoietic stem and progenitor cell function: Good guys or bad guys?
When hematopoietic stem and progenitor cells (HSPC) are harvested for transplantation, either from the bone marrow or from mobilized blood, the graft contains a significant number of T cells. It is these T cells that are the major drivers of graft-vs-host disease (GvHD). The risk for GvHD can simply be reduced by the removal of these T cells from the graft. However, this is not always desirable...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Blood
سال: 2012
ISSN: 0006-4971,1528-0020
DOI: 10.1182/blood-2011-12-398719