Gold-Catalyzed Intermolecular Alkyne Oxyarylation for C3 Functionalization of Benzothiophenes
نویسندگان
چکیده
C3-selective C–C bond formation on benzothiophenes is challenging, and few direct functionalization methods are available. A gold-catalyzed reaction of alkynes with benzothiophene S-oxides provides regioselective entry into C3-alkylated the C7-alkylated isomer as minor product. This oxyarylation works alkyl aryl substituted unsubstituted benzothiophenes. Mechanistic studies identify that sulfoxide inhibits catalyst [DTBPAu(PhCN)]SbF6, which also degrades forms unreactive complex [(DTBP)2Au]SbF6.
منابع مشابه
Regioselective functionalisation of dibenzothiophenes through gold-catalysed intermolecular alkyne oxyarylation.
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ژورنال
عنوان ژورنال: Organic Letters
سال: 2021
ISSN: ['1523-7060', '1523-7052']
DOI: https://doi.org/10.1021/acs.orglett.0c03596