GnRH Agonist Acts as Ovarian Protection in Chemotherapy Induced Gonadotoxicity: An Experiment Using a Rat Model
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چکیده
منابع مشابه
GnRH agonist acts as ovarian protection in chemotherapy induced gonadotoxicity: an experiment using a rat model.
To reduce chemotherapy induced gonadotoxicity, co-treatment with gonadotropin releasing hormone against analogue (GnRHa) was tested using rat model. Leuprorelin acetate (Leuplin) with or without cisplatin (CDDP) was given subcutaneously at a dose of 9.4 microg/ml to Wistar strain female rats. The total number of follicles was counted and the maturation of follicles was evaluated at the largest ...
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Approximately 40 000 adolescent and young adult females between the ages of 15 and 39 years are diagnosed with cancer yearly. The high survival rate ofmany cancers has broadened the focus of what is considered an optimal clinical outcome to include preservation of ovarian function. Ovarian function has many implications for the cancer survivor including fertility, bonehealth andpsychosocial wel...
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چکیده ندارد.
Protection of ovarian function by GnRH agonists during chemotherapy: a meta-analysis.
This meta-analysis was designed to assess the overall performance of GnRHa in preserving the ovarian function in young women undergoing chemotherapy. Electronic literature databases including Pubmed, MEDLINE, Cochrane library, Embase, CNKI and Wanfang were searched for articles published till November, 2013. The articles written in both Chinese and English were considered. Only randomized contr...
متن کاملAssessment of fertility protection and ovarian reserve with GnRH antagonist in rats undergoing chemotherapy with cyclophosphamide
BACKGROUND Reproductive function following chemotherapy is of increasing importance given that survival rates are improving. We assessed whether a gonadotropin-releasing hormone antagonist (GnRHant; cetrorelix) could promote ovarian protection against damage due to chemotherapy. METHODS Forty-two female Wistar rats were used in this study. Animals were divided into four groups: group I (n=9) ...
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ژورنال
عنوان ژورنال: The Kurume Medical Journal
سال: 2007
ISSN: 0023-5679,1881-2090
DOI: 10.2739/kurumemedj.54.25