منابع مشابه
GMFβ prunes actin branches
Migrating fi broblasts assemble a dendritic network of branched actin fi laments that drives the formation of a lamellipodial protrusion at their leading edge. Haynes et al. reveal that, like a topiarist guiding the growth of a tree, a protein called GMF " prunes " this actin network in order to guide the cell's migration towards certain directional cues (1). Branched actin networks form when ...
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متن کاملLamellipodial actin branches out
Many cell types, including fi broblasts and epithelial cells, move forward by forming an actin-rich membrane protrusion, called a lamellipodium, at the front of the cell. In the early 1990s, researchers thought that lamellipodial protrusion was driven by the polymerization of linear actin fi laments. In two JCB papers published in 1997 and 1999, however, Tatyana Svitkina and colleagues revealed...
متن کاملGMFβ controls branched actin content and lamellipodial retraction in fibroblasts
The lamellipodium is an important structure for cell migration containing branched actin nucleated via the Arp2/3 complex. The formation of branched actin is relatively well studied, but less is known about its disassembly and how this influences migration. GMF is implicated in both Arp2/3 debranching and inhibition of Arp2/3 activation. Modulation of GMFβ, a ubiquitous GMF isoform, by depletio...
متن کاملActin branches out in yeast
Actin branches out in yeast any of the same proteins control actin polymerization in budding yeast and mammalian cells. But budding yeast researchers—hampered by an emphasis on genetics and an inaccessible yeast cytoplasm dense with ribosomes and glycogen granules—have often lagged behind in providing structural descriptions based on electron microscopy (EM). This has fueled suspicions about wh...
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ژورنال
عنوان ژورنال: Journal of Cell Biology
سال: 2015
ISSN: 1540-8140,0021-9525
DOI: 10.1083/jcb.2096if