Glycosaminoglycan chains of biglycan promote bone morphogenetic protein-4-induced osteoblast differentiation

Glycosaminoglycan chains of biglycan promote bone morphogenetic protein-4-induced osteoblast differentiation.

Biglycan (BGN) has been reported to promote bone morphogenetic protein-4 (BMP-4) stimulated osteoblastic differentiation. However, the underlying mechanism has yet to be fully elucidated. The glycosaminoglycan (GAG) chains of BGN have a variety of biological functions. In the present study, we explored the potential role of the GAG chains of BGN in promoting BMP-4-induced osteoblast differentia...

Blocking c-Met signaling enhances bone morphogenetic protein-2-induced osteoblast differentiation

We previously demonstrated that blocking hepatocyte growth factor (HGF) receptor/c-Met signaling inhibited arthritis and articular bone destruction in mouse models of rheumatoid arthritis (RA). In the present study, we investigated the role of c-Met signaling in osteoblast differentiation using the C2C12 myoblast cell line derived from murine satellite cells and the MC3T3-E1 murine pre-osteobla...

Biglycan Modulation of Bone Morphogenetic Protein-2 Functions

Patricia A. Miguez Biglycan Modulation of Bone Morphogenetic Protein-2 Functions (Under the direction of Professor Mitsuo Yamauchi) Biglycan (BGN) is a proteoglycan found in high abundance in mineralized tissues. Study of its functions has unveiled roles in collagen organization (i.e. type VI), osteoblast differentiation, matrix mineralization, inflammatory processes, etc. Recently, we have rep...

Cilomilast enhances osteoblast differentiation of mesenchymal stem cells and bone formation induced by bone morphogenetic protein 2.

A rapid and efficient method to stimulate bone regeneration would be useful in orthopaedic stem cell therapies. Rolipram is an inhibitor of phosphodiesterase 4 (PDE4), which mediates cyclic adenosine monophosphate (cAMP) degradation. Systemic injection of rolipram enhances osteogenesis induced by bone morphogenetic protein 2 (BMP-2) in mice. However, there is little data on the precise mechanis...

Regulates Early Thymocyte Differentiation Bone Morphogenetic Protein 2/4 Signaling