Glycoprotein (GP) Ib beta is the critical subunit linking GP Ib alpha and GP IX in the GP Ib-IX complex. Analysis of partial complexes.
نویسندگان
چکیده
منابع مشابه
Aggregation of mammalian cells expressing the platelet glycoprotein (GP) Ib-IX complex and the requirement for tyrosine sulfation of GP Ib alpha.
The glycoprotein (GP) Ib-IX complex mediates platelet aggregation in response to high shear forces by binding von Willebrand factor (vWF) in the plasma. We investigated the possibility that the complex could mediate a similar phenomenon if expressed in nonhematopoietic cells. When agitated on a tabletop shaker, CHO and L cells expressing the full complex formed large aggregates in the presence ...
متن کاملMembrane skeleton orchestrates the platelet glycoprotein (GP) Ib‐IX complex clustering and signaling
Platelet glycoprotein Ib-IX complex is affixed to the membrane skeleton through interaction with actin binding protein 280 (ABP-280). We find that removal of the ABP-280 binding sites in GP Ibα cytoplasmic tail has little impact on the complex clustering induced by antibody crosslinking. However, large truncation of the GP Ibα cytoplasmic tail allows the formation of larger patches of the compl...
متن کاملKozak sequence polymorphism of the glycoprotein (GP) Ibalpha gene is a major determinant of the plasma membrane levels of the platelet GP Ib-IX-V complex.
Despite the known importance of the sequences surrounding ATG start codons (Kozak sequences) for efficient translation of proteins, few reports have appeared that describe the natural variations in these sequences. Here, we report a human polymorphism in the Kozak sequence of the platelet adhesion receptor, glycoprotein (GP) Ibalpha, a component of the GP Ib-IX-V complex, which mediates the ini...
متن کاملAggregation of Mammalian Cells Expressing the Platelet Glycoprotein (GP) Ib-IX Complex and the Requirement for Tyrosine Sulfation of GP Iba!
The glycoprotein (GP) Ib-IX complex mediates platelet aggregation in response to high shear forces by binding von Willebrand factor (vWF) in the plasma. We investigated the possibility that the complex could mediate a similar phenomenon if expressed in nonhematopoietic cells. When agitated on a tabletop shaker, CH0 and L cells expressing the full complex formed large aggregates inthe presence o...
متن کاملADAP IS REQUIRED FOR NORMAL αIIbβ3 ACTIVATION BY VWF/GP Ib-IX-V AND OTHER AGONISTS
Department of Medicine, University of California San Diego, La Jolla, CA; Department of Molecular and Experimental Medicine, The Scripps Research Institute, La Jolla, CA; Department of Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA; Institute of Immunology, University of Magdeburg, Magdeburg, Germany; and Abramson Family Cancer Research Institute and Division...
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ژورنال
عنوان ژورنال: Journal of Biological Chemistry
سال: 1994
ISSN: 0021-9258
DOI: 10.1016/s0021-9258(17)31574-0