Glycine Dissolution Behavior under Forced Convection

The integration of a flow-through cell into Mach–Zehnder interferometer offers the possibility to study dissolution crystals in detail. influence flow on displacement velocity specific crystal facet and distribution solute concentration around are measured simultaneously time-resolved manner. disintegration from surface mass transfer solvent can be separated. We aim establish an vitro experiment that improves quality prediction for bioavailability active pharmaceutical ingredients. In presented feasibility study, glycine was used as model substance. It successfully demonstrated set-up is suitable observing separately. description rate terms Sherwood number function Reynolds, Schmidt Grashof numbers clearly shows with increasing there transition natural forced convection dominant mechanism. Temporal spatial resolved fields visualize convective also show diffusive boundary layer. No limitation by could found examined range rates.