Glutenin is involved in the gluten-driven mucosal T cell response

The gluten response in children with celiac disease is directed toward multiple gliadin and glutenin peptides.

BACKGROUND & AIMS Gluten (GLU)-specific T-cell responses in HLA-DQ2 positive adult celiac disease (CD) patients are directed to an immunodominant alpha-gliadin (GLIA) peptide that requires deamidation for T-cell recognition. The aim of the current study was to determine which GLU peptide(s) are involved early in disease. METHODS We have characterized the GLU-specific T-cell response in HLA-DQ...

Chapter 1 Gluten: A Balance of Gliadin and Glutenin

CD1d is involved in T cell-intestinal epithelial cell interactions

We assessed the role of the nonclassical class I molecule, CD1d, in the interaction between intestinal epithelial cells and T cells. In a mixed lymphocyte reaction (MLR) system where the stimulator cells were irradiated normal intestinal cells, the anti-CD1d monoclonal antibody (mAb) 3C11 inhibited T cell proliferation. In contrast, no inhibition was seen when mAb 3C11 was added to conventional...

Evidence for antigen-driven T-cell response in unstable angina.

BACKGROUND Activation of T cells and macrophages has been associated with unstable angina (UA), but whether this reflects specific immune responses remains unclear. METHODS AND RESULTS We analyzed the repertoire and the length of complementarity-determining region 3 of the T-cell receptor (TCR) beta-chain variable (BV) gene segments of activated lymphocytes in 23 patients with UA, 13 patients...

cGMP signaling pathway is involved in Leyding cell stress response

The ability of stress to interfere with the Leydig cell steroidogenesis has been published previously by others and our laboratory, but the intracellular signaling pathways involved in this process have not been identified and described precisely. In this study, we examined the effects of immobilization stress (1 × 120 min, 2 × 120 min within 2 days, and 10 × 120 min within 10 days) on nitric o...