Glutathione transferases: a structural perspective
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چکیده
منابع مشابه
Glutathione transferases: a structural perspective.
The glutathione transferases (GSTs) are one of the most important families of detoxifying enzymes in nature. The classic activity of the GSTs is conjugation of compounds with electrophilic centers to the tripeptide glutathione (GSH), but many other activities are now associated with GSTs, including steroid and leukotriene biosynthesis, peroxide degradation, double-bond cis-trans isomerization, ...
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Class-Pi of glutathione s-transferases (GST-Pi) is the specific form of GSTs that are known to participate particularly in the mechanisms of resistance to drugs and carcinogens. This class of the enzyme is referred to as class-P or class-Pi or class π. The accepted terminology in this review article is class-Pi. In this article following a brief description of identified molecular forms of GSTs...
متن کاملMolecular biology of glutathione transferases
immunochemically detectable protein, and catalytic activity in different liver samples (Distlerath et al., 1985; Shimada et al., 1986; Umbenhauer et al., 1986). However, rat P-450,,,., , the orthologue of P-450,,, and its activities are well correlated with levels of the 2000 nucleotide mRNA(s) coding for the protein (Churchill et al., 1987); this regulatory model does not seem appropriate for ...
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Two immunologically distinct types of 22000-Mr subunits are present in rat lung glutathione S-transferases. One of these subunits is probably similar to Ya subunits of rat liver glutathione S-transferases, whereas the other subunit Ya' is immunologically distinct. Glutathione S-transferase II (pI7.2) of rat lung is a heterodimer (YaYa') of these subunits, and glutathione S-transferase VI (pI4.8...
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Background: The glutathione S-transferase (GST) family of metabolising enzymes plays an important role in the detoxification of mutagens and carcinogens. The expression of many of these cancer susceptibility enzymes is genetically polymorphic. An increased frequency of GST-null genotypes has been associated with several malignancies. Objective: To investigate the rate of GSTT1 and GSTM1 null ge...
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ژورنال
عنوان ژورنال: Drug Metabolism Reviews
سال: 2011
ISSN: 0360-2532,1097-9883
DOI: 10.3109/03602532.2011.558093