Glutathione Synthesis and Turnover in the Human Erythrocyte
نویسندگان
چکیده
منابع مشابه
The turnover of erythrocyte glutathione in the rat.
Several observations have been reported which suggest that the intact rat erythrocyte is able to synthesize and destroy glutathione (GSH). Anderson and Mosher (1) detected radioactivity in the erythrocyte GSH of rats following the administration of Wlabeled cystine. In this laboratory it has been observed that C14-labeled glycine is rapidly incorporated into the GSH of rat red cells in vitro (2...
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Patients with septic shock have high plasma glutathione concentrations, whereas intracellular concentrations in erythrocytes and muscle are low. In the present study, we investigated the temporal pattern of glutathione status and glutathione kinetics in healthy volunteers during the initial phase of sepsis using a human endotoxin model. The present study was a descriptive pilot study in healthy...
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Glutathione peroxidase has been purified to homogeneity from human erythrocytes. The purification steps involved ammonium sulfate precipitation of hemolysate, CM-cellulose (CM-52), DEAE-cellulose (DE52), Sephadex G-200, and DEAE-Sephadex column chromatography. In the last step, i.e. DEAE-Sephadex A-25 column chromatography, the enzyme was eluted in a major peak and tailing fraction. The major p...
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Glutathione synthetase (GSH-S) is one of the two known hereditary causes of glutathione deficiency. We describe a family whose two children have hemolytic anemia. The children's erythrocytes lack GSH and are severely deficient in GSH-S activity. No neurologic findings or 5-oxoprolinuria were present. A concurrent deficiency of glutathione-S-transferase (GST) was also detected in the erythrocyte...
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ژورنال
عنوان ژورنال: Journal of Biological Chemistry
سال: 2010
ISSN: 0021-9258
DOI: 10.1074/jbc.m109.067017