Glutaminolysis-induced mTORC1 activation drives non-alcoholic steatohepatitis progression

Glutaminolysis feeds mTORC1

Glutamine is an important amino acid from a metabolic point of view. As an amino acid and a precursor for other amino acids, it sustains protein synthesis. It is also required for production of nucleotides (pyrimidines) and α-ketoglutarate (αKG). αKG is produced via double deamination of glutamine, a process termed glutaminolysis. Glutamine is first de-aminated by glutaminase (GLS) to produce g...

Non-alcoholic steatohepatitis

Non-invasive biomarkers in non-alcoholic steatohepatitis-induced hepatocellular carcinoma.

Non-alcoholic fatty liver disease (NAFLD) is by far the most common form of chronic liver disease worldwide, affecting adults as well as children. Under the term of NAFLD there is a wide spectrum of diseases ranging from simple steatosis to the non-alcoholic steatohepatitis (NASH), which can progress to cirrhosis and hepatocellular carcinoma (HCC). Several mechanisms have been described to infl...

Non-alcoholic steatohepatitis in children.

Non-alcoholic steatohepatitis (NASH) is an important liver disease in children; it can cause cirrhosis in children. The disease mechanism involves hepatic insulin resistance with hyperinsulinemia and changes in certain adipocytokines and inflammatory mediators. The differential diagnosis of childhood NASH includes metabolic disorders, drug hepatotoxicity, and alcoholic hepatitis in adolescent p...

[Non-alcoholic fatty liver disease and non-alcoholic steatohepatitis].

Non-alcoholic fatty liver disease (NAFLD) and non-alcoholic steatohepatitis (NASH) are the hepatic manifestations of the metabolic syndrome. Since the prevalence of obesity and consequently of the metabolic syndrome is steadily increasing, the different types of NAFLD are nowadays the most common cause of liver injury in North America. The development of NASH and fatty liver cirrhosis occurs af...