منابع مشابه
Glutaminolysis feeds mTORC1
Glutamine is an important amino acid from a metabolic point of view. As an amino acid and a precursor for other amino acids, it sustains protein synthesis. It is also required for production of nucleotides (pyrimidines) and α-ketoglutarate (αKG). αKG is produced via double deamination of glutamine, a process termed glutaminolysis. Glutamine is first de-aminated by glutaminase (GLS) to produce g...
متن کاملmTORC1 inhibition in cancer cells protects from glutaminolysis-mediated apoptosis during nutrient limitation
A master coordinator of cell growth, mTORC1 is activated by different metabolic inputs, particularly the metabolism of glutamine (glutaminolysis), to control a vast range of cellular processes, including autophagy. As a well-recognized tumour promoter, inhibitors of mTORC1 such as rapamycin have been approved as anti-cancer agents, but their overall outcome in patients is rather poor. Here we s...
متن کاملRole of SNAT1 in glutaminolysis
Many cancer cells depend on glutamine as they use the glutaminolysis pathway to generate building blocks and energy for anabolic purposes. As a result, glutamine transporters are essential for cancer growth and are potential targets for cancer chemotherapy, with ASCT2 (SLC1A5) being investigated most intensively. Here we show that HeLa epithelial cervical cancer cells and 143B osteosarcoma cell...
متن کاملGlycolysis, glutaminolysis and cell proliferation.
Since the original observation that a high rate of aerobic glycolysis is a hallmark of malignant cells (Warburg, 1926), considerable effort has been devoted to elucidation of the role of glycolysis in normal and transformed cell proliferation. Many explanations have been put forward to explain the high flux of glucose to lactate in proliferating normal and transformed cells (Warburg, 1926; Papa...
متن کاملGlutaminolysis gets the spotlight in cancer
The fact that cancer cells rewire their metabolism to meet their extreme energetic and biosynthetic needs has long been known, since the seminal studies by Otto Warburg demonstrated that cancer cells heavily rely on glycolysis even in the presence of oxygen, the so-called Warburg effect. However, efforts to therapeutically target the special requirements of cancer cells have only gained tractio...
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ژورنال
عنوان ژورنال: Cell Cycle
سال: 2012
ISSN: 1538-4101,1551-4005
DOI: 10.4161/cc.22632