Glucosylceramides Stimulate Mitogenesisin Aged Murine Epidermis
نویسندگان
چکیده
منابع مشابه
Glucosylceramides stimulate murine epidermal hyperproliferation.
Hydrolysis of glucosylceramides (GlcCer) by beta-glucocerebrosidase generates ceramides, critical components of the epidermal permeability barrier. Ceramides also are involved in the regulation of cellular proliferation and differentiation in a variety of cell types. Whereas most studies have focused on ceramides and their sphingoid base metabolites as growth inhibitors, GlcCer apparently acts ...
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Six series of glucosylceramides from pig epidermis have been identified, and their structures have been determined. The structural types identified are: 1, N-acylglucosylsphingosines (33%); 2, N-acylglucosylphytosphingosines (13%); 3, N-(omega-hydroxyacyl)-glucosylsphingosines (3%); 4, N-(alpha-hydroxyacyl)-glucosylphingosines (15%); 5, N-(alpha-hydroxyacyl)-glucosylsphingosines (16%); 6, N-(al...
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Keratinocytes require abundant cholesterol for cutaneous permeability barrier function; hence, the regulation of cholesterol homeostasis is of great importance. ABCA1 is a membrane transporter responsible for cholesterol efflux and plays a pivotal role in regulating cellular cholesterol levels. We demonstrate that ABCA1 is expressed in cultured human keratinocytes (CHKs) and murine epidermis. L...
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T cell progenitors are known to arise from the foetal liver in embryos and the bone marrow in adults; however different studies have shown that a pool of T cell progenitors may also exist in the periphery. Here, we identified a lymphoid population resembling peripheral T cell progenitors which transiently seed the epidermis during late embryogenesis in both wild-type and T cell-deficient mice. ...
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ABCG1, a member of the ATP binding cassette superfamily, facilitates the efflux of cholesterol from cells to HDL. In this study, we demonstrate that ABCG1 is expressed in cultured human keratinocytes and murine epidermis, and induced during keratinocyte differentiation, with increased levels in the outer epidermis. ABCG1 is regulated by liver X receptor (LXR) and peroxisome proliferator-activat...
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ژورنال
عنوان ژورنال: Journal of Investigative Dermatology
سال: 1998
ISSN: 0022-202X
DOI: 10.1046/j.1523-1747.1998.00145.x