Glucose oxidase‐instructed biomineralization of calcium‐based biomaterials for biomedical applications

In recent years, glucose oxidase (GOx) has aroused great research interest in the treatment of diseases related to abnormal metabolisms like cancer and diabetes. However, as a kind endogenous oxido-reductase, GOx suffers from poor stability system toxicity vivo. order overcome this bottleneck, is encapsulated calcium-based biomaterials (CaXs) such calcium phosphate (CaP) carbonate (CaCO3) by using it biotemplate simulate natural biomineralization process. The biomineralized holds improved reduced side effects, due excellent bioactivity, biocompatibitliy, biodegradability CaXs. review, state-of-the-art studies on GOx-mineralized CaXs are introduced with an emphasis their application various biomedical fields including disease diagnosis, treatment, diabetes management. current challenges future perspectives discussed, which expected promote further these smart for practical applications.