منابع مشابه
Effect of Glucose-Insulin-Potassium Infusion
The effects of glucose-insulin-potassium (GIK) infusion and glucose (G) infusion started 30 min after experimental coronary occlusion and the combination of GIK and propranolol (P) started 3 hours after coronary occlusion on the development of myocardial infarction were studied in 37 dogs. Fifteen minutes after the coronary occlusion, epicardial electrocardiograms were recorded at 10-15 sites; ...
متن کاملThe Protective Effect of Glucose-Insulin-Potassium
1. Gaffney TE, Sigell LT, Mohammed S, Atkinson AJ: The clinical pharmacology of antihypertensive drugs. Prog Cardiovas Dis 12: 52, 1969 2. Oates JA, Mitchell JR, Feagin OT, Kaufmann JS, Shand DG: Distribution of guanidinium antihypertensives mechanism of their selective action. Ann NY Acad Sci 197: 302, 1971 3. Nickerson M, Ruedy J: Antihypertensive agents and the drug therapy of hypertension. ...
متن کاملGlucose, insulin and potassium for heart protection during cardiac surgery.
BACKGROUND Coronary artery bypass grafting with hypothermic cardiac arrest and cardiopulmonary bypass (CPB) is associated with myocardial injury. Our study investigated whether an infusion of glucose, insulin and potassium (GIK) during elective coronary artery bypass surgery decreases myocardial cell death. METHODS We measured cardiac troponin I (cTnI), a myofibrillar structural protein, whic...
متن کاملBlock of Kv1.7 potassium currents increases glucose-stimulated insulin secretion
Glucose-stimulated insulin secretion (GSIS) relies on repetitive, electrical spiking activity of the beta cell membrane. Cyclic activation of voltage-gated potassium channels (K(v) ) generates an outward, 'delayed rectifier' potassium current, which drives the repolarizing phase of each spike and modulates insulin release. Although several K(v) channels are expressed in pancreatic islets, thei...
متن کامل[Glucose--insulin--potassium (GIK) in acute myocardial infarction].
Myocardial Infarction To the Editor: As my mentor Dr William Dock said, medical practice is like a pendulum: it swings back and forth every 20 to 30 years. Sodi-Pallares et al1 in 1962 introduced the glucose-insulinpotassium infusion (GIK) for treatment of acute myocardial infarction. It was also called the “polarizing solution,”2 but little did they know that this solution indeed polarized the...
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ژورنال
عنوان ژورنال: Circulation
سال: 2011
ISSN: 0009-7322,1524-4539
DOI: 10.1161/circulationaha.110.002709