Glucocorticoids suppress macrophage migration inhibitory factor (MIF) expression in a cell-type-specific manner
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منابع مشابه
Glucocorticoids suppress macrophage migration inhibitory factor (MIF) expression in a cell-type-specific manner.
MIF is a potent proinflammatory cytokine involved in inflammatory arthritis. Glucocorticoids (GC) have been reported to induce secretion of MIF in rodent cells, and as MIF counteracts the anti-inflammatory effects of GC, this has implications for human inflammatory disease. Transient transfection studies showed that the MIF promoter was repressed by dexamethasone (Dex) (10 nM) in CEM C7A cells,...
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Abstract Background: Despite the long-standing association of macrophage migration inhibitory factor (MIF) with delayed-type hypersensitivity response, the potential role of MIF in chronic allograft nephropathy is unknown. The association between upregulation of MIF expression, macrophage and T cell infiltration and the severity of chronic allograft nephropathy suggests that MIF may be an ...
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ژورنال
عنوان ژورنال: Journal of Molecular Endocrinology
سال: 2005
ISSN: 0952-5041,1479-6813
DOI: 10.1677/jme.1.01647