Glucocorticoid receptors
نویسندگان
چکیده
منابع مشابه
Ketoconazole Binds to Glucocorticoid Receptors
A B S T R A C T We have recently found that ketoconazole inhibits adrenal steroidogenesis; in this paper we investigated whether imidazole antimycotic drugs additionally interact with glucocorticoid receptor sites in target tissues. Our approach was to assess the ability of three drugs: ketoconazole, clotrimazole, and RS 49910, to inhibit [3H]dexamethasone binding to hepatoma tissue culture (HT...
متن کاملGlucocorticoid Receptors in Lymphoid Tumors1
There ¡sa range of levels of glucocorticoid receptor numbers seen in the various subclasses of acute lymphatic leukemia (ALL). This variability cannot be explained by the known cor relation between active cell proliferation and an increase in the number of receptors, since the tumors with the highest growth fraction (i.e., Burkitt's lymphoma and T-cell leukemia) tend to have lower average rece...
متن کاملP92: Investigation of the Role of Glucocorticoid Receptors on the Anxiety in Mice: A Preliminary Report
Some studies suggested that glucocorticoid receptors activities can modulate fear and anxiety. According to that, the purpose of this research is to assess the modulatory effect of glucocorticoid receptors on the anxiety assessed in plus maze. In this research mice with medium weight of 20-25 g were used. The male and female animals separately sorted in two groups as control and experiment rand...
متن کاملDifferent Gene Expressions of Alpha and Beta Glucocorticoid Receptors in Asthmatics
The response to glucocorticoids (GCs) therapy classifies severe refractory asthma (SRA) and mild asthma, so the glucocorticoid receptors (GCRs) gene expression may be involved in SRA pathogenesis. Thus, it is aimed to compare the expression levels of two GCR isoforms (GCRα and GCRβ) in SRA, mild asthmatics, and healthy controls. Total RNA was isolated from the peripheral blood mononuclear lymph...
متن کاملDifferent Gene Expressions of Alpha and Beta Glucocorticoid Receptors in Asthmatics
The response to glucocorticoids (GCs) therapy classifies severe refractory asthma (SRA) and mild asthma, so the glucocorticoid receptors (GCRs) gene expression may be involved in SRA pathogenesis. Thus, it is aimed to compare the expression levels of two GCR isoforms (GCRα and GCRβ) in SRA, mild asthmatics, and healthy controls. Total RNA was isolated from the peripheral blood mononuclear lymph...
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ژورنال
عنوان ژورنال: Japanese Journal of Pharmacology
سال: 1978
ISSN: 0021-5198
DOI: 10.1016/s0021-5198(19)53102-x