Glucocerebrosidase expression patterns in the non-human primate brain
نویسندگان
چکیده
منابع مشابه
Oral ambroxol increases brain glucocerebrosidase activity in a nonhuman primate
Mutations in the glucocerebrosidase 1 (GBA1) gene are related to both Parkinson disease (PD) and Gaucher disease (GD). In both cases, the condition is associated with deficiency of glucocerebrosidase (GCase), the enzyme encoded by GBA1. Ambroxol is a small molecule chaperone that has been shown in mice to cross the blood-brain barrier, increase GCase activity and reduce alpha-synuclein protein ...
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ژورنال
عنوان ژورنال: Brain Structure and Function
سال: 2017
ISSN: 1863-2653,1863-2661
DOI: 10.1007/s00429-017-1504-1