Glucagon-Like Peptide 1 Stimulates Hypothalamic Proopiomelanocortin Neurons
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چکیده
منابع مشابه
Glucagon-like peptide 1 stimulates hypothalamic proopiomelanocortin neurons.
Glucagon-like peptide 1 (GLP-1) is a potent inhibitor of food intake. GLP-1 receptor mRNA is densely expressed in hypothalamic arcuate nucleus (ARC) and precisely overlaps the area occupied by proopiomelanocortin (POMC) neurons. Activation of POMC neurons suppresses appetite, and lack of POMC-derived peptides or inhibition of POMC neuronal firing causes obesity. Here, we identify living POMC ce...
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ژورنال
عنوان ژورنال: Journal of Neuroscience
سال: 2007
ISSN: 0270-6474,1529-2401
DOI: 10.1523/jneurosci.1025-07.2007