Glu298Asp Endothelial Nitric Oxide Synthase Polymorphism Is a Risk Factor for Erectile Dysfunction in the Mexican Mestizo Population
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چکیده
منابع مشابه
AB197. Endothelial nitric oxide synthase polymorphism and erectile dysfunction risk: evidence based on a meta-analysis
Objective: To clarify the antioxidation role in diabetic ED treatment by a long-term administration of PDE5I. Methods: Three groups of Sprague-Dawley rats were utilized: group N, normal control; group D, streptozotocin (STZ) induced diabetic rats as control; group D + T, STZ induced diabetic rats by the intragastric administration with tadalafil for 8 weeks. Results: ICP/MAP ratio was significa...
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BACKGROUND Altered expression of endothelial nitric oxide synthase (eNOS) has been reported to be involved in the development of endometriosis. The genotypes of eNOS gene (NOS3) may be responsible for variation in its enzymatic activity as well as plasma concentration of nitric oxide. The Glu298Asp polymorphism of the NOS3 may modulate angiogenesis and influence individual susceptibility to end...
متن کاملAssociation Between the Glu298Asp Polymorphism in the Endothelial Constitutive Nitric Oxide Synthase Gene and Brain Infarction
Background and Purpose—Nitric oxide (NO) synthesized by endothelial constitutive NO synthase (ecNOS) plays a key role in vascular regulation and atherosclerosis. Little is known concerning the role of the ecNOS gene (NOS3) as a risk factor for brain infarction (BI). Our aim was to investigate the relation between the Glu298Asp polymorphism in exon 7 of NOS3 with BI and its subtypes. Methods—Pat...
متن کاملA common variant of endothelial nitric oxide synthase (Glu298Asp) is an independent risk factor for carotid atherosclerosis.
BACKGROUND AND PURPOSE Endothelium-derived NO is formed from L-arginine by endothelial NO synthase (eNOS) encoded by the NOS 3 gene on chromosome 7. Because several studies have indicated that NO plays a key role in the development of the atherosclerotic process, we investigated whether common variants in the eNOS gene are associated with an increased risk of plaque on carotid arteries. METHO...
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To investigate the effect of hyperhomocysteinaemia (HHCy) on penile erectile function in a rat model, a methionine-rich diet was used in which erectile function, the reproductive system, and nitric oxide synthase were characterized. The intracavernous pressure, apomorphine experiments, measurement of oxidative stress, hematoxylin and eosin staining, immunohistochemistry analysis, reverse transc...
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ژورنال
عنوان ژورنال: Journal of Andrology
سال: 2004
ISSN: 0196-3635
DOI: 10.1002/j.1939-4640.2004.tb02847.x