Global Tn-seq analysis of carbohydrate utilization and vertebrate infectivity ofBorrelia burgdorferi
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چکیده
منابع مشابه
Carbohydrate utilization by the Lyme borreliosis spirochete, Borrelia burgdorferi.
Growth kinetic analyses of Borrelia burgdorferi indicated that this bacterium can utilize a limited number of carbon sources for energy: the monosaccharides glucose, mannose, and N-acetylglucosamine, the disaccharides maltose and chitobiose, and glycerol. All of these carbohydrates are likely to be available to B. burgdorferi during infection of either vertebrate and arthropod hosts, enabling d...
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15 صفحه اولDissociation of infectivity and pathogenicity in Borrelia burgdorferi.
Clonal Borrelia burgdorferi N40 (cN40) passaged 75 times in vitro (N40-75) infects mice but does not cause disease. N40-75 passaged 45 times further in vitro (N40-120) was no longer infectious and lacked genes encoded on linear plasmids 38 and 28-1, among other differences. These data suggest that B. burgdorferi cN40, N40-75, and N40-120 have distinct phenotypes that can be used to dissect the ...
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ژورنال
عنوان ژورنال: Molecular Microbiology
سال: 2016
ISSN: 0950-382X
DOI: 10.1111/mmi.13437