Global Subcellular Characterization of Protein Degradation Using Quantitative Proteomics
نویسندگان
چکیده
منابع مشابه
Global Subcellular Characterization of Protein Degradation Using Quantitative Proteomics*
Protein degradation provides an important regulatory mechanism used to control cell cycle progression and many other cellular pathways. To comprehensively analyze the spatial control of protein degradation in U2OS osteosarcoma cells, we have combined drug treatment and SILAC-based quantitative mass spectrometry with subcellular and protein fractionation. The resulting data set analyzed more tha...
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ژورنال
عنوان ژورنال: Molecular & Cellular Proteomics
سال: 2013
ISSN: 1535-9476
DOI: 10.1074/mcp.m112.024547