Global protein interactome exploration through mining genome-scale data in Arabidopsis thaliana

Global protein function annotation through mining genome-scale data in yeast Saccharomyces cerevisiae.

As we are moving into the post genome-sequencing era, various high-throughput experimental techniques have been developed to characterize biological systems on the genomic scale. Discovering new biological knowledge from the high-throughput biological data is a major challenge to bioinformatics today. To address this challenge, we developed a Bayesian statistical method together with Boltzmann ...

Global characterization of Arabidopsis protein interactome

The network of all protein-protein interactions (PPIs) in an organism, named as the interactome, is a powerful tool for understanding biological processes as an integrated system. Studies in several model species indicate that interactomes exhibit some unique features, such as the scale-free topology and the correlations with genomic information. Here we constructed an Arabidopsis interactome c...

Inferring the Brassica rapa Interactome Using Protein–Protein Interaction Data from Arabidopsis thaliana

Following successful completion of the Brassica rapa sequencing project, the next step is to investigate functions of individual genes/proteins. For Arabidopsis thaliana, large amounts of protein-protein interaction (PPI) data are available from the major PPI databases (DBs). It is known that Brassica crop species are closely related to A. thaliana. This provides an opportunity to infer the B. ...

A Predicted Interactome for Arabidopsis thaliana

Sulfenome mining in Arabidopsis thaliana.

Reactive oxygen species (ROS) have been shown to be potent signaling molecules. Today, oxidation of cysteine residues is a well-recognized posttranslational protein modification, but the signaling processes steered by such oxidations are poorly understood. To gain insight into the cysteine thiol-dependent ROS signaling in Arabidopsis thaliana, we identified the hydrogen peroxide (H2O2)-dependen...