GLIS3 binds pancreatic beta cell regulatory regions alongside other islet transcription factors
نویسندگان
چکیده
منابع مشابه
Transcription factor Glis3, a novel critical player in the regulation of pancreatic beta-cell development and insulin gene expression.
In this study, we report that the Krüppel-like zinc finger transcription factor Gli-similar 3 (Glis3) is induced during the secondary transition of pancreatic development, a stage of cell lineage specification and extensive patterning, and that Glis3(zf/zf) mutant mice develop neonatal diabetes, evidenced by hyperglycemia and hypoinsulinemia. The Glis3(zf/zf) mutant mouse pancreas shows a drama...
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ژورنال
عنوان ژورنال: Journal of Endocrinology
سال: 2019
ISSN: 0022-0795,1479-6805
DOI: 10.1530/joe-19-0182