Glioblastoma Multiforme with a Peculiar Chromosomal Aberration—Double Minute Chromosomes
نویسندگان
چکیده
منابع مشابه
Double minute chromosomes in glioblastoma multiforme are revealed by precise reconstruction of oncogenic amplicons.
DNA sequencing offers a powerful tool in oncology based on the precise definition of structural rearrangements and copy number in tumor genomes. Here, we describe the development of methods to compute copy number and detect structural variants to locally reconstruct highly rearranged regions of the tumor genome with high precision from standard, short-read, paired-end sequencing datasets. We fi...
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متن کاملTumor and Stem Cell Biology Double Minute Chromosomes in Glioblastoma Multiforme Are Revealed by Precise Reconstruction of Oncogenic Amplicons
DNA sequencing offers a powerful tool in oncology based on the precise definition of structural rearrangements and copy number in tumor genomes. Here, we describe the development of methods to compute copy number and detect structural variants to locally reconstruct highly rearranged regions of the tumor genome with high precision from standard, short-read, paired-end sequencing datasets.Wefind...
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ژورنال
عنوان ژورنال: Neurologia medico-chirurgica
سال: 1987
ISSN: 0470-8105,1349-8029
DOI: 10.2176/nmc.27.789