Glimepiride protects neurons against amyloid-β-induced synapse damage
نویسندگان
چکیده
منابع مشابه
cAMP-Inhibits Cytoplasmic Phospholipase A2 and Protects Neurons against Amyloid-β-Induced Synapse Damage
A key event in Alzheimer's disease (AD) is the production of amyloid-β (Aβ) peptides and the loss of synapses. In cultured neurons Aβ triggered synapse damage as measured by the loss of synaptic proteins. α-synuclein (αSN), aggregates of which accumulate in Parkinson's disease, also caused synapse damage. Synapse damage was associated with activation of cytoplasmic phospholipase A₂ (cPLA₂), an ...
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ژورنال
عنوان ژورنال: Neuropharmacology
سال: 2016
ISSN: 0028-3908
DOI: 10.1016/j.neuropharm.2015.09.030