Glial cell line?derived neurotrophic factor increases matrix metallopeptidase 9 and 14 expression in microglia and promotes microglia?mediated glioma progression

نویسندگان

چکیده

Glial cell line-derived neurotrophic factor (GDNF) is released by glioma cells and promotes tumor growth. We have previously found that GDNF from the a chemoattractant for microglial cells, immune of central nervous system. Here we show increases matrix metalloproteinase (MMP) 9 MMP14 expression in cultured mixed sexes neonatal mice. The GDNF-induced MMP9 upregulation mediated family receptor alpha 1 receptors dependent on p38 mitogen-activated protein kinase signaling. In organotypic brain slices, growth this effect depends presence microglia. also can be Toll-like (TLR) 2 signaling here demonstrate TLR1 TLR2. conclusion, pro-tumorigenic phenotype

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ژورنال

عنوان ژورنال: Journal of Neuroscience Research

سال: 2021

ISSN: ['0360-4012', '1097-4547']

DOI: https://doi.org/10.1002/jnr.24768