Ghrelin Cells in the Gastrointestinal Tract

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Ghrelin Cells in the Gastrointestinal Tract

Ghrelin is 28-amino-acid peptide that was discovered from the rat and human stomach in 1999. Since the discovery of ghrelin, various functions of ghrelin, including growth hormone release, feeding behavior, glucose metabolism, memory, and also antidepressant effects, have been studied. It has also been reported that ghrelin in the gastrointestinal tract has an important physiological effect on ...

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INTRODUCTION Ghrelin, an appetite-stimulating hormone secreted by the endocrine cells of the gastrointestinal (GI) tract, has recently been shown to affect the function of the cardiovascular system. This study aimed to assess the number and morphology of ghrelin-immunopositive (GhrIP) cells in the gastrointestinal tract of rats at different developmental phases of experimentally evoked renovasc...

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Ghrelin and oxidative stress in gastrointestinal tract

Oxidative stress is a major cause of the gastrointestinal damage under physical or psychological stress. Ghrelin exhibits gastroprotective effects and they are supposed to be derived from antioxidant effects. In gastroduodenal mucosal injury, the plasma ghrelin levels increase in response to the demand for gastroduodenal cytoprotection. However, in the condition of Helicobacter pylori-induced g...

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Ghrelin in the postnatal development of the gastrointestinal tract.

Ghrelin is a 28-amino acid peptide first isolated from rat and human stomachs. Together with the recently discovered 23-amino acid obestatin, it is derived from proghrelin by posttranslational processing. Cells immunoreactive to ghrelin are widely distributed in the gastric mucosa in domestic and laboratory animals and in humans. Ghrelin plays an important role in energy homeostasis, body weigh...

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Ghrelin, the 'hunger' hormone, is an endogenous growth hormone secretagogue that exerts a wide range of physiological functions. Its perinatal presence suggests that ghrelin might be involved in growth and metabolism processes during intrauterine and postnatal life. Intrauterine growth-restricted (IUGR) neonates have altered endocrine and metabolic pathways because of malnutrition during foetal...

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ژورنال

عنوان ژورنال: International Journal of Peptides

سال: 2010

ISSN: 1687-9767,1687-9775

DOI: 10.1155/2010/945056