Gfi1 functions downstream of Math1 to control intestinal secretory cell subtype allocation and differentiation
نویسندگان
چکیده
منابع مشابه
Gfi1 regulates intestinal and gastric epithelial differentiation downstream of Notch
Gfi1 is a transcriptional repressor involved in directing differentiation of secretory precursors into goblet and paneth cells in the intestinal epithelium. Gfi 1 is downstream of the Notch signaling pathway, responsible in regulating expression of counter transcription factors Atoh 1 (secretory) and Hes 1, (absorptive). Recent reports describe Notch activity in gastric epithelium, but there ar...
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Notch signaling is active in many sites, and its diverse activities must require tissue-specific intermediaries, which are largely unknown. In the intestinal epithelium, Notch promotes crypt cell proliferation and inhibits goblet cell differentiation. Pharmacologic studies suggest that the latter effect occurs through the transcription factor Math1/Atoh1, which specifies all intestinal secretor...
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Intestinal cells are constantly produced from a stem cell reservoir that gives rise to proliferating transient amplifying cells, which subsequently differentiate into one of the four principal cell types. Signalling pathways, including the Notch signalling pathway, coordinate these differentiation processes and their deregulation may cause cancer. Pharmacological inhibition through γ-secretase ...
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ژورنال
عنوان ژورنال: Genes & Development
سال: 2005
ISSN: 0890-9369
DOI: 10.1101/gad.1353905