Getting close. Lysosome-ER contact sites tailor Ca2+ signals
نویسندگان
چکیده
منابع مشابه
A computational model of lysosome-ER Ca2+ microdomains.
Acidic organelles form an important intracellular Ca(2+) pool that can drive global Ca(2+) signals through coupling with endoplasmic reticulum (ER) Ca(2+) stores. Recently identified lysosome-ER membrane contact sites might allow formation of Ca(2+) microdomains, although their size renders observation of Ca(2+) dynamics impractical. Here, we generated a computational model of lysosome-ER coupl...
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NAADP (nicotinic acid-adenine dinucleotide phosphate) is a potent Ca2+-mobilizing messenger implicated in many Ca2+-dependent cellular processes. It is highly unusual in that it appears to trigger Ca2+ release from acidic organelles such as lysosomes. These signals are often amplified by archetypal Ca2+ channels located in the endoplasmic reticulum. Recent studies have converged on the TPCs (tw...
متن کاملSar1, a Novel Regulator of ER-Mitochondrial Contact Sites.
Endoplasmic reticulum (ER)-mitochondrial contact sites play a pivotal role in exchange of lipids and ions between the two organelles. How size and function of these contact sites are regulated remains elusive. Here we report a previously unanticipated, but conserved role of the small GTPase Sar1 in the regulation of ER-mitochondrial contact site size. Activated Sar1 introduces membrane curvatur...
متن کاملThe “sweet” side of ER-mitochondria contact sites
ARTICLE HISTORY Received 28 April 2017 Accepted 9 May 2017 ABSTRACT The regions at which the ER and mitochondria come into close proximity, known as ERmitochondria contact sites provide essential platforms for the exchange of molecules between the two organelles and the coordination of various fundamental cellular processes. In addition to the well-established role of ER-mitochondria interfaces...
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ژورنال
عنوان ژورنال: Cell Calcium
سال: 2019
ISSN: 0143-4160
DOI: 10.1016/j.ceca.2019.02.003