Get off the back burner!

Get off the back burner!

A 65-year-old male presented with chronic mechanical back pain and a 6-month history of a discrete, hyperpig-mented reticular rash on his lower back. On further questioning, the patient admitted to daily use of an electric heating pad over the distribution of the rash (Figure 1). The diagnosis was erythema ab igne (EAI). Historically, EAI has been associated with repeated and prolonged exposure...

Inner city medicine: off the back burner.

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Get off my back! Rapid receptor internalization through circular dorsal ruffles.

Internalization and subsequent trafficking of receptor tyrosine kinases (RTKs) play an important role in the modulation of growth factor-stimulated signaling events that affect different cellular processes, from cell growth and mitosis to motility and invasion. The intracellular transport of these receptors has traditionally been viewed as being initiated via clathrin-coated pits. However, nonc...

Get off your butt- and live longer.