Germline Pathogenic Variants in 7636 Japanese Patients With Prostate Cancer and 12 366 Controls
نویسندگان
چکیده
منابع مشابه
Prevalence of pathogenic germline variants detected by multigene sequencing in unselected Japanese patients with ovarian cancer
Pathogenic germline BRCA1, BRCA2 (BRCA1/2), and several other gene variants predispose women to primary ovarian, fallopian tube, and peritoneal carcinoma (OC), although variant frequency and relevance information is scarce in Japanese women with OC. Using targeted panel sequencing, we screened 230 unselected Japanese women with OC from our hospital-based cohort for pathogenic germline variants ...
متن کاملGermline Variants of Prostate Cancer in Japanese Families
Prostate cancer (PC) is the second most common cancer in men. Family history is the major risk factor for PC. Only two susceptibility genes were identified in PC, BRCA2 and HOXB13. A comprehensive search of germline variants for patients with PC has not been reported in Japanese families. In this study, we conducted exome sequencing followed by Sanger sequencing to explore responsible germline ...
متن کاملDetermining the frequency of pathogenic germline variants from exome sequencing in patients with castrate-resistant prostate cancer.
OBJECTIVES To determine the frequency of pathogenic inherited mutations in 157 select genes from patients with metastatic castrate-resistant prostate cancer (mCRPC). DESIGN Observational. SETTING Multisite US-based cohort. PARTICIPANTS Seventy-one adult male patients with histological confirmation of prostate cancer, and had progressive disease while on androgen deprivation therapy. RES...
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We conducted the largest investigation of predisposition variants in cancer to date, discovering 853 pathogenic or likely pathogenic variants in 8% of 10,389 cases from 33 cancer types. Twenty-one genes showed single or cross-cancer associations, including novel associations of SDHA in melanoma and PALB2 in stomach adenocarcinoma. The 659 predisposition variants and 18 additional large deletion...
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ژورنال
عنوان ژورنال: JNCI: Journal of the National Cancer Institute
سال: 2019
ISSN: 0027-8874,1460-2105
DOI: 10.1093/jnci/djz124