Geometrical and Electronic Structure Variability of the Sugar−phosphate Backbone in Nucleic Acids
نویسندگان
چکیده
منابع مشابه
Backbone modification of nucleic acids: synthesis, structure and therapeutic applications.
Nucleic acids have been extensively modified by replacing the phosphodiester group or the whole sugar phosphodiester with alternative anionic, neutral and cationic structures. Several of these modified oligonucleotides exhibit improved properties including enhanced recognition and binding to RNA, duplex DNA and proteins. This has resulted in the development of new and more potent antisense and ...
متن کاملDetermination of the backbone structure of nucleic acids and nucleic acid oligomers by laser Raman scattering.
Raman spectra of fibers of DNA that have been prepared in the A, B, and C forms are presented and compared with Raman spectra of DNA and RNA in dilute solution. It is shown that the phosphate vibrations in the region 750-850 cm(-1) are very sensitive to the specific conformation of the phosphate group in the backbone chain and are virtually independent of all ohter factors. Thus, a very simple ...
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ژورنال
عنوان ژورنال: The Journal of Physical Chemistry B
سال: 2008
ISSN: 1520-6106,1520-5207
DOI: 10.1021/jp801245h