Genus level analysis of PKS-NRPS and NRPS-PKS hybrids reveals their origin in Aspergilli
نویسندگان
چکیده
منابع مشابه
NRPS-PKS: a knowledge-based resource for analysis of NRPS/PKS megasynthases
NRPS-PKS is web-based software for analysing large multi-enzymatic, multi-domain megasynthases that are involved in the biosynthesis of pharmaceutically important natural products such as cyclosporin, rifamycin and erythromycin. NRPS-PKS has been developed based on a comprehensive analysis of the sequence and structural features of several experimentally characterized biosynthetic gene clusters...
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Background Actinomycetes may account for 10 to 30% of the total soil rhizosphere microorganisms. The attention given to the actinomycetes in biotechnological applications is a result of their metabolic versatility that is accompanied by the production of primary and secondary metabolites of economic importance, which are a promising source of products (e.g., antibiotics, enzyme inhibitors, anti...
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ClusterMine360 (http://www.clustermine360.ca/) is a database of microbial polyketide and non-ribosomal peptide gene clusters. It takes advantage of crowd-sourcing by allowing members of the community to make contributions while automation is used to help achieve high data consistency and quality. The database currently has >200 gene clusters from >185 compound families. It also features a uniqu...
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Marine environments harbor a wide range of microorganisms from the three domains of life. These microorganisms have great potential to enable discovery of new enzymes and bioactive compounds for industrial use. However, only ~1% of microorganisms from the environment can currently be identified through cultured isolates, limiting the discovery of new compounds. To overcome this limitation, a me...
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Polyketides and nonribosomal peptides represent two large families of natural products (NPs) with diverse structures and important functions. They are synthesized by polyketide synthase (PKS) and nonribosomal peptide synthetase (NRPS), respectively. Lysobacter enzymogenes is emerging as a novel biocontrol agent against pathogens of crop plants and a new source of bioactive NPs, such as antibact...
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ژورنال
عنوان ژورنال: BMC Genomics
سال: 2019
ISSN: 1471-2164
DOI: 10.1186/s12864-019-6114-2