Gentamycin elution from polymethylmethacrylate and bone graft substitute: Comparison between commercially available and home-made preparations
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چکیده
منابع مشابه
Optimized elution of daptomycin from polymethylmethacrylate beads.
We demonstrate that xylitol can be added to polymethylmethacrylate (PMMA) bone cement to enhance the elution of daptomycin in terms of both the peak and sustained release of antibiotic. We also demonstrate that a PMMA-xylitol formulation optimized for daptomycin can be used to enhance the elution of both vancomycin and gentamicin.
متن کاملElution of metronidazole and gentamicin from polymethylmethacrylate beads.
OBJECTIVE To characterize the elution and bioactivity of metronidazole and gentamicin sulfate polymerized, individually and in combination, with polymethylmethacrylate (PMMA). STUDY DESIGN In vitro experimental study. METHODS PMMA beads containing metronidazole (3 concentrations), gentamicin sulfate, or metronidazole and gentamicin sulfate were immersed in 5 mL of phosphate-buffered saline ...
متن کاملAntimicrobial properties and elution kinetics of linezolid from polymethylmethacrylate.
Polymethylmethacrylate (PMMA) impregnated with antibiotics is widely used in the treatment of osteomyelitis and infected arthroplasties. With the emergence of resistant bacterial strains, linezolid, which is active against gram-positive bacteria and toward which resistance has been scarce, has been suggested as an alternative. In the current in vitro study, the authors sought to determine and c...
متن کاملDetermining Vitamin D Status: A Comparison between Commercially Available Assays
BACKGROUND Vitamin D is not only important for bone health but can also affect the development of several non-bone diseases. The definition of vitamin D insufficiency by serum levels of 25-hydroxyvitamin D depends on the clinical outcome but might also be a consequence of analytical methods used for the definition. Although numerous 25-hydroxyvitamin D assays are available, their comparability ...
متن کاملPharmacokinetics of gentamicin eluted from a regenerating bone graft substitute
OBJECTIVES Deep bone and joint infections (DBJI) are directly intertwined with health, demographic change towards an elderly population, and wellbeing.The elderly human population is more prone to acquire infections, and the consequences such as pain, reduced quality of life, morbidity, absence from work and premature retirement due to disability place significant burdens on already strained he...
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ژورنال
عنوان ژورنال: Journal of Orthopaedics
سال: 2020
ISSN: 0972-978X
DOI: 10.1016/j.jor.2019.11.034