Gentamicin nephrotoxicity: Animal experimental correlate with human pharmacovigilance outcome
نویسندگان
چکیده
منابع مشابه
Long-term protection of polyaspartic acid in experimental gentamicin nephrotoxicity.
Polyaspartic Acid (PAA) protects the kidney from experimental gentamicin nephrotoxicity despite large increases in renal cortical gentamicin content. In these experiments, prominent cytoplasmic vacuoles were noted in all animals that received PAA with or without gentamicin. The present study showed that there were no renal structural or functional consequences of PAA given alone or with gentami...
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Context: Gentamicin is an antibiotic used in gram-negative infection. It is an nephrotoxic agent. Proximal tubular epithelial cells are selectively sensitive to gentamicin. Objective: To observe the toxic effect of gentamicin on epithelial cells of proximal convoluted tubule in Long Evans rats. Study design: An experimental study. Plan and period of study: The study was carried out in the Depar...
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TO STUDY THE POSSIBILITY THAT CEPHALOSPORINS AUGMENT THE NEPHROTOXICITY OF GENTAMICIN, GROUPS OF RATS WERE GIVEN FOUR HOURLY SUBCUTANEOUS DOSES OF: gentamicin (5 mg/kg), gentamicin plus cephalothin (100 mg/kg), gentamicin plus cefazolin (20 mg/kg), gentamicin plus cefazolin (50 mg/kg), gentamicin plus cephaloridine (50 mg/kg), or saline diluent for 15 days. Periodic measurements were made of ur...
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Gentamicin blood levels were monitored in 86 patients. Twenty-one patients had valley levels over 2 mug/ml and 36% of these patients developed abnormal serum creatinine or a further rise in creatinine. No patient had a rise in creatinine without a valley level over 2. The peak levels in patients with valleys over 2 were above 10 mug/ml in only one case, whereas four patients had peaks over 10 m...
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Renal damage was assessed by measuring urinary enzyme excretion in 180 patients with renal allografts. Thirty-six of these patients were studied during 53 courses of treatment with antimicrobial agents which was the only antimicrobial agent which was associated with an increase in urinary enzyme activity. There was usually also evidence of reduced renal function. Renal morphological changes sim...
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ژورنال
عنوان ژورنال: Biomedical Journal
سال: 2015
ISSN: 2319-4170
DOI: 10.4103/2319-4170.131387