Genotypic Studies of Carbapenem Resistant Acinetobacter baumanii (CRAB) with Special Reference to Presence of OXA bla Genes

بررسی ژن‌های اگزاسیلیناز در ایزوله‌های بالینی اسینتوباکتربامانی مقاوم به کرباپنم در بیمارستان شهید محمدی بندرعباس درسال 1393

Background and Objective: Acinetobacter baumannii is considered as an important agent in nosocomial infections. The problem facing the tratment of these bacteria is increasing resistance to antimicrobial agents such as carbapenems. The main mechanism of resistance to carbapenems in these bacteria is the presence of  oxacillinases genes, which belong to class D betalactamases. The aim of this st...

Carbapenem-resistant Acinetobacter baumannii producing OXA-23 in Thailand.

We investigated the resistance determinant of 13 clinical isolates of carbapenem-resistant Acinetobacter baumannii collected from a regional hospital in the north of Thailand. All isolates were multidrug resistant and produced the OXA-23 carbapenemase. The bla(OXA-23) gene was found adjacent to ISAba1. Furthermore, two isolates carried the metallo beta-lactamase gene, bla(IMP). The bla(OXA-23) ...

Phenotypic and Genotypic Detection of Metallo-Beta-Lactamases in Carbapenem Resistant Acinetobacter baumannii

Polyclonal spread of bla(OXA-23) and bla(OXA-58) in Acinetobacter baumannii isolates from Argentina.

BACKGROUND In order to study the enzymatic carbapenem resistance mechanisms in Acinetobacter baumannii isolates from Argentina, we performed molecular characterization on 41 epidemiologically unrelated strains isolated from 1995 to 2006 with diminished susceptibilities to imipenem and meropenem. METHODOLOGY Acinetobacter baumannii isolates were identified with the ARDRA technique. The total g...

Glimpse into the genome sequence of a multidrug-resistant Acinetobacter pittii ST950 clinical isolate carrying the bla OXA-72 and bla OXA-533 genes in China

The development of carbapenem-resistant Acinetobacter species is of serious concern in the hospital settings and naturally occurring oxacillinase genes (blaOXA) have been identified in several Acinetobacter species. In this study, we report the genome sequence of A. pittii TCM178 belongs to ST950, a multidrug-resistant isolate that harbored the blaOXA-72 and blaOXA-533 genes simultaneous. The g...