Genotype‐phenotype correlation of unusual BCR‐ABL1 transcripts in Philadelphia chromosome‐positive leukaemia

The e1a3 BCR-ABL1 Fusion Transcript in Philadelphia Chromosome-Positive Acute Lymphoblastic Leukemia

Dear Editor In a recent issue of Annals of Laboratory Medicine, Shin and colleagues described two cases of Philadelphia chromosomepositive (Ph+) ALL expressing e1a3 BCR-ABL1 gene fusion product and listed other cases reported thus far that involve this fusion [1]. A basic literature review using the search term “e1a3” reveals two additional adult cases that should have been included in this lis...

Eosinophilic leukaemia in association with a double Philadelphia chromosome.

A case of eosinophilic leukaemia in association with chromosomal abnormalities including a double Philadelphia chromosome is reported. Comment is also made on the cardiological problems which arise in this condition.

Patients in Focus: What’s Relevant for Chronic Myeloid Leukaemia and Philadelphia Chromosome-positive Acute Lymphoblastic Leukaemia?

EMJ EUROPEAN MEDICAL JOURNAL HEMATOLOGY • August 2017 • Creative Commons Attribution-Non Commercial 4.0 EMJ EUROPEAN MEDICAL JOURNAL 52 53 PATIENTS IN FOCUS: WHAT’S RELEVANT FOR CHRONIC MYELOID LEUKAEMIA AND PHILADELPHIA CHROMOSOME-POSITIVE ACUTE LYMPHOBLASTIC LEUKAEMIA? This satellite symposium took place on 22nd June 2017 as part of the 22nd European Hematology Association (EHA) Congress in M...

The Philadelphia chromosome in an unusual case of myeloproliferative disease.

Congenital leukaemia: an unusual cause of stillbirth.

Three cases of congenital leukaemia associated with hydrops and intrauterine death are described. The leukaemic infiltrates, which involved both the infants and the placentas, were of monocytic, lymphoblastic, and myeloblastic types, respectively. The general lack of recognition of the condition is probably due to inadequate histological examination of the stillborn infant and the placenta.