Genotype 5 Japanese Encephalitis Virus—Old Genotype, New Threat

Japanese encephalitis (JE) is an important viral with epidemic status in Asia, which caused by virus (JEV), a member of the genus Flavivirus . JEV divided into five genotypes. Genotype 5 (G5) relatively neglected because limited number cases and strains isolated. The first strain G5 (Muar strain) was isolated Singapore 1952 patient from Muar, Malaysia. second (XZ0934) 57 years later China, thus indicating re-emergence JEV. A female who had been vaccinated against JE infected Korea 2015. vaccine-preventable disease, its incidence has decreased vaccination many Asian countries. G3 main candidate for current vaccines, include attenuated, inactivated chimeric type vaccines. However, available vaccines do not provide adequate protection older lineage. Therefore, more research on this genotype crucial developing better detection methods, expanding surveillance to determine possible chains transmission new threat polyvalent vaccine.