Genotoxicity of synthetic dyes with umu test using Salmonella typhimurium TA1535/pSK1002. (II).
نویسندگان
چکیده
منابع مشابه
[Genotoxicity of synthetic dyes in umu test using Salmonella typhimurium TA1535/pSK1002 (1). Results of examination for acid dyes, direct dyes, disperse dyes and reactive dyes].
The umu test system is a newly developed method to evaluate genotoxicities of a wide variety of environmental carcinogens and mutagens (Oda et al., 1985; Nakamura et al., 1987). In the present study, SOS-inducing activity of 142 synthetic dyes was investigated by the umu test using Salmonella typhimurium (TA1535/pSK1002) under the condition of absence and presence of rat liver microsomal fracti...
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The present study embodied the mutagenic/genotoxic potential of two most commonly used synthetic food dyes, viz., sky blue and orange red, employing Ames Salmonella histidine reversion point mutation assay and Allium cepa root chromosomal aberration assay. It was observed that sky blue and orange red dyes showed 6-fold increase in TA100 strain from the spontaneous count, whereas they showed non...
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Four types of phytoncide solution (A-Type, AB-Type, D-Type and G-Type) were evaluated as antimutagenic agents with suppressive effects on the SOS-inducing activity of the mutagen 2-(2-furyl)-3-(5-nitro-2-furyl) acrylamide (furylfuramide) using Salmonella typhimurium TA1535/pSK1002 umu test. The A-Type, AB-Type, D-Type and G-Type of phytoncide solution suppressed the SOS-inducing activity on fur...
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The Escherichia coli mu operon was subcloned into a pKK233-2 vector containing rat glutathione S-transferase (GST) 5-5 cDNA and the plasmid thus obtained was introduced into Salmonella typhimurium TA1535. The newly developed strain S.typhimurium NM5004, was found to have 52-fold greater GST activity than the original umu strain S.typhimurium TA1535/pSK1002. We compared sensitivities of these tw...
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A previously developed and highly sensitive umu-microplate test system based on the nitroreductase- and O-acetyltransferase-overproducing strain Salmonella typhimurium NM3009 and the O-acetyltransferase-overproducing strain S. typhimurium NM2009 was applied to the detection of genotoxic activity in atmospheric particles in urban areas using a relatively small sample load. The results showed tha...
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ژورنال
عنوان ژورنال: Sangyo Igaku
سال: 1990
ISSN: 0047-1879,1881-1302
DOI: 10.1539/joh1959.32.319