Genomic Test Validation for Incidental Findings
نویسندگان
چکیده
منابع مشابه
Genomic test validation for incidental findings.
In March of 2013, the American College of Medical Genetics and Genomics (ACMG) issued recommendations for the reporting of incidental findings produced by clinical exome and genome sequencing (1, 2 ). This guideline on incidental findings has been controversial, because the recommendations are a departure from previous ethical concepts of patient autonomy and the reporting of adult-onset diseas...
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The Human Genome Project showed that there is significant genetic variation within the population. Current research is accumulating large databases that may reveal genetic variations associated with disease or health risks, even if not intended as part of the study design. These incidental findings create legal, ethical, and financial challenges for researchers. Current federal and internationa...
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This paper summarizes the current controversies surrounding the identification and disclosure of "incidental" or "secondary" findings from genomic sequencing and the implications for genetic counseling practice. The rapid expansion of clinical sequencing has influenced the ascertainment and return of incidental findings, while empiric data to inform best practices are still being generated. Usi...
متن کاملDefining and managing incidental findings in genetic and genomic practice.
The rapidly declining costs and increasing speeds of whole-genome analysis mean that genetic testing is undergoing a shift from targeted approaches to broader ones that look at the entire genome. As whole-genome technologies gain widespread use, questions about the management of so-called incidental findings-those unrelated to the question being asked-need urgent consideration. In this review, ...
متن کاملIncidental Findings ? THE DUTY TO RESCUE IN GENOMIC RESEARCH
Gliwa et al. (2012) focus their analysis of researcher obligations for incidental findings in genomic research on three criteria: (1) the benefit to the research participant, which requires strong associations with severe disease that has medical actionability; (2) unique access to the information and analysis; and (3) the burden that looking and returning incidental findings places on the rese...
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ژورنال
عنوان ژورنال: Clinical Chemistry
سال: 2014
ISSN: 0009-9147,1530-8561
DOI: 10.1373/clinchem.2013.210609