Genomic c-Myc Quadruplex DNA Selectively Kills Leukemia
نویسندگان
چکیده
منابع مشابه
Therapeutic Discovery Genomic c-Myc Quadruplex DNA Selectively Kills Leukemia
c-Myc, a key regulator of cell cycle andproliferation, is commonly overexpressed in leukemia and associated with poor prognosis. Conventional antisense oligonucleotides targeting c-myc may attenuate leukemic cell growth, however, are poorly taken into cells, rapidlydegraded, andhaveunwanted effects onnormal cells. The c-myc promoter contains a guanine-rich sequence (PU27) capable of forming qua...
متن کاملGenomic c-Myc quadruplex DNA selectively kills leukemia.
c-Myc, a key regulator of cell cycle and proliferation, is commonly overexpressed in leukemia and associated with poor prognosis. Conventional antisense oligonucleotides targeting c-myc may attenuate leukemic cell growth, however, are poorly taken into cells, rapidly degraded, and have unwanted effects on normal cells. The c-myc promoter contains a guanine-rich sequence (PU27) capable of formin...
متن کاملTarget guided synthesis using DNA nano-templates for selectively assembling a G-quadruplex binding c-MYC inhibitor
The development of small molecules is essential to modulate the cellular functions of biological targets in living system. Target Guided Synthesis (TGS) approaches have been used for the identification of potent small molecules for biological targets. We herein demonstrate an innovative example of TGS using DNA nano-templates that promote Huisgen cycloaddition from an array of azide and alkyne ...
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Regulatory influence of the G-quadruplex or G4 motif present within the nuclease hypersensitive element (NHE) in the promoter of c-MYC has been noted. On the other hand, association of NM23-H2 to the NHE leads to c-MYC activation. Therefore, NM23-H2 interaction with the G4 motif within the c-MYC NHE presents an interesting mechanistic possibility. Herein, using luciferase reporter assay and chr...
متن کاملc-MYC-induced genomic instability.
MYC dysregulation initiates a dynamic process of genomic instability that is linked to tumor initiation. Early studies using MYC-carrying retroviruses showed that these viruses were potent transforming agents. Cell culture models followed that addressed the role of MYC in transformation. With the advent of MYC transgenic mice, it became obvious that MYC deregulation alone was sufficient to init...
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ژورنال
عنوان ژورنال: Molecular Cancer Therapeutics
سال: 2011
ISSN: 1535-7163,1538-8514
DOI: 10.1158/1535-7163.mct-11-0515