Genome-wide transcriptome profiling of homologous recombination DNA repair
نویسندگان
چکیده
منابع مشابه
Genome-wide Transcriptome Profiling of Homologous Recombination DNA Repair
Homologous recombination (HR) repair deficiency predisposes to cancer development, but also sensitizes cancer cells to DNA damage-inducing therapeutics. Here we identify an HR defect (HRD) gene signature that can be used to functionally assess HR repair status without interrogating individual genetic alterations in cells. By using this HRD gene signature as a functional network analysis tool, w...
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Nonallelic homologous recombination (NAHR), occurring between low-copy repeats (LCRs) >10 kb in size and sharing >97% DNA sequence identity, is responsible for the majority of recurrent genomic rearrangements in the human genome. Recent studies have shown that transposable elements (TEs) can also mediate recurrent deletions and translocations, indicating the features of substrates that mediate ...
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Gene Control, second edition, is a concise book that focuses on gene expression and regulation in eukaryotes. Synonymous with the first edition, the chapters build on themselves, culminating in a discussion correlating gene control in regard to human health and disease. The author uses illustrations where appropriate, focusing on simplistic figures that correlate DNA, RNA, and regulatory protei...
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Activity-dependent gene expression is central for sculpting neuronal connectivity in the brain. Despite the importance for synaptic plasticity, a comprehensive analysis of the temporal changes in the transcriptomic response to neuronal activity is lacking. In a genome wide survey we identified genes that were induced at 1, 4, 8, or 24 hours following neuronal activity in the hippocampus. Accord...
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ژورنال
عنوان ژورنال: Nature Communications
سال: 2014
ISSN: 2041-1723
DOI: 10.1038/ncomms4361