Genome-wide identification of transcriptional targets of RORA reveals direct regulation of multiple genes associated with autism spectrum disorder
نویسندگان
چکیده
منابع مشابه
Genome-wide identification of transcriptional targets of RORA reveals direct regulation of multiple genes associated with autism spectrum disorder
BACKGROUND We have recently identified the nuclear hormone receptor RORA (retinoic acid-related orphan receptor-alpha) as a novel candidate gene for autism spectrum disorder (ASD). Our independent cohort studies have consistently demonstrated the reduction of RORA transcript and/or protein levels in blood-derived lymphoblasts as well as in the postmortem prefrontal cortex and cerebellum of indi...
متن کاملThe Impact of Emotion Regulation Training on Social Skills of Children with Autism Spectrum Disorder
Background and Purpose: Since children with autism spectrum disorder are at risk for emotional and social problems, the purpose of this study was to investigate the effectiveness of emotional regulation training on social skills of children with autism spectrum disorder. Methods: The research method was quasi-experimental with pretest-posttest and control group design. For this purpose, 25 chil...
متن کاملComparison of Motor Skills in At-risk with Autism Spectrum Disorder Children with Autism Spectrum Disorder and Typical Development Children
Background: Autism Spectrum Disorder (ASD) is a complex developmental disorder characterized by repetitive and stereotypical patterns, and difficulties with social communication and interaction in early childhood. Motor development and dysfunction in children with ASD has been the subject of study in recent years and has attracted much of the attention of researchers. As motor dysfunctions can ...
متن کاملLiterature Review-Fathers of Children with Autism Spectrum Disorder
Objectives: The involvement of parents in raising children with autism spectrum disorder (ASD) is crucial for both the child's development and family functioning. However, studies relating to parental involvement in parenting children with ASD mainly focus on the mother's perspective, resulting in a lack of understanding of the father's role. On the other hand, the father involvement in parenti...
متن کاملThe Impact of a Family-Centered Problem-Solving Program on Emotional Regulation of Mothers of Students with Autism Spectrum Disorder
This study set out to determine the impact of a family-centered problem-solving program on emotional regulation of mothers of students with autism spectrum disorder. The research had a pretest-posttest control group design with a follow-up session. The statistical population of the study was comprised of all mothers of students with autism spectrum disorder in Kermanshah in 2018-19 school year....
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Molecular Autism
سال: 2013
ISSN: 2040-2392
DOI: 10.1186/2040-2392-4-14