Genome-Wide Association Studies Provoke Debate and a New Look at Strategy
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چکیده
منابع مشابه
Genome-wide association studies provoke debate and a new look at strategy.
G enomewide association studies (GWAS), which began with hopes of quickly uncovering the genetic underpinnings of disease and personalizing treatment and risk prediction, are now the subject of debate in both academic journals and the general media. GWAS use microarrays to scan thousands of tissue samples from patients with a particular disease and compare the results with samples from healthy ...
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Recently genetic studies have been revolutionized by next generation sequencing (NGS) technology, and it is expected that the use of this technology will largely eliminate defects in the methods of association studies. The NGS technology is becoming the premier tool in genetics. However, at the moment the use of this method is limited especially in the livestock due to high cost and computation...
متن کاملGenome-wide Association Studies
Progress in probabilistic generative models has accelerated, developing richer models with neural architectures, implicit densities, and with scalable algorithms for their Bayesian inference. However, there has been limited progress in models that capture causal relationships, for example, how individual genetic factors cause major human diseases. In this work, we focus on two challenges in par...
متن کاملGenome-wide Association Studies
Progress in probabilistic generative models has accelerated, developing richer models with neural architectures, implicit densities, and with scalable algorithms for their Bayesian inference. However, there has been limited progress in models that capture causal relationships, for example, how individual genetic factors cause major human diseases. In this work, we focus on two challenges in par...
متن کاملGenome-wide association studies.
Genome-wide association (GWA) studies are best understood as an extension of candidate gene association studies, scaled up to cover hundreds of thousands of markers across the genome in samples usually of several thousand cases and controls. The GWA approach allows the detection of much smaller effect sizes than with previous linkage-based genome-wide studies. However, this sensitivity makes th...
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ژورنال
عنوان ژورنال: JNCI Journal of the National Cancer Institute
سال: 2009
ISSN: 0027-8874,1460-2105
DOI: 10.1093/jnci/djp244